Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Pseudomonas aeruginosa | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | metalloprotease | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibronectin + H2O | Pseudomonas aeruginosa | - |
? | - |
? | |
Vitronectin + H2O | Pseudomonas aeruginosa | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
gene lasB | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibronectin + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
Vitronectin + H2O | - |
Pseudomonas aeruginosa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LasB | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
malfunction | the exosecretome of the LasB-deficient pseudomonal strain PAO1lasBDELTA has limited impact on human vascular cell adherence and viability | Pseudomonas aeruginosa |
physiological function | Pseudomonal LasB cleaves extracellular matrix proteins involved in adherence of vascular stromal cells in human host. LasB can induce vascular cell anoikis in human cells through simultaneous proteolysis of extracellular matrix components and cell receptors, suggesting the uPAR-vitronectin axis as a major target in this process. In heart valves of patients occurs extensive, LasB-dependent degradation of extracellular matrix-associated fibronectin and vitronectin, that preceeds cell de-adherence, whereas type I collagen shows limited degradation. Disruption of cell/ECM interactions resulting from uncontrolled pericellular proteolysis leads to detachment-induced cell apoptosis, anoikis, contributing to the morbid evolution of inflammatory vascular diseases, overview | Pseudomonas aeruginosa |